Vitamin C revisited

Vitamin C revisited

This narrative review summarizes the role of vitamin C in mitigating oxidative injury-induced microcirculatory impairment and associated organ failure in ischemia/reperfusion or sepsis. Preclinical studies show that high-dose vitamin C can prevent or restore microcirculatory flow impairment by inhibiting activation of nicotinamide adenine dinucleotide phosphate-oxidase and inducible nitric oxid...

Vitamin C and cancer revisited.

I n this issue of PNAS, Chen et al. (1) show that i.p. injection of ‘‘pharmacologic doses’’ of vitamin C decreases the growth and weight of human, rat, and murine tumor xenografts in athymic, nude mice. This work follows a number of articles by the same group, led by Mark Levine at the National Institute of Diabetes and Digestive and Kidney Diseases, showing that millimolar concentrations of ex...

Vitamin C and Oxidative DNA Damage Revisited

Reactive oxygen metabolites can pro­ mote carcinogenesis by damaging DNA. vi­ tamin C is a redox chemical with antioxi­ dant and pro-oxidant properties that may produce radical species depending on the presence of various conditions. Nevertheless, evidence presented herein discourages the consideration of any mutagenic or carcino­ genic activity of vitamin C. In contrast, it substantiates a pro...

Vitamin C and COVID-19

  Corona disease has killed at least 5 million people globally since it started in Wuhan, China in December 2019 (World Health Organization, 2021). The disease is caused by SARS-COVID-19, and is transmitted from person to person by respiratory droplets (Baladia et al., 2020, Ejaz et al., 2020). Although the early symptoms of COVID-19  include fever, weariness, headache, sore throat, cough, d...

Vitamin C.